Publications

Publications:

(33) A. N. Bismillah, A. Bismuto, A. Blakney, S. Callens, C. Calvino, S. Crespi, R. Cruz-Acuna, A Daly, L. Davenport Huyer, J. H. Docherty, L. Donnelly, J. A. Finbloom, P. Gurnani, R. Hein, J. Johnstone-Hack, S. E. Leggett, N. Leisgang, J. Y.C. Lim, K. Neumann, Matter Cell Press, 2025, accepted.

35(+1) Challenges in materials science being tackled by PIs under 35(ish) in 2025

(32) N. R. Schneider, A. M. Orlova, N. D. Kumarage, P. Theato*, K. Neumann*, Macromolecular Rapid Communication, 2025, accepted.

Hydrophilic Poly(Iminopyridinium Ylide)s: Defining a New Chemical Space for Poly(ylide)s

(31) D. M. Sánchez-Cerrillo, K. Shiraishi*, L. Mallen-Huertas, R. Peters, D. A. Wilson*, K. Neumann*, JACS Au, 2025, 5, 9, 4378–4388.

Introducing Sulfur Ylides as Charge-Neutral Termini for Mitigating Poly(Ethylene Glycol) Antigenicity in Nanomedicine

(30) K. Gavriel, D. Deissenbeck, T. J. Rutjes, D. W . T. Geers, J. Meisner*, K. Neumann*, ChemistryEurope, 2025, e202500273.

Programmable Site-Selectivity: pH-Modulated Triazine-Thiol Exchange for Site- and Chemoselective Cysteine Labelling

(29) J. S. Willems, D. M. Sánchez-Cerrillo, K. Gavriel, K. Neumann* ACS Polymer Au 2025, 5, 5, 537–544.

Multi post-polymerization functionalization of PLA enabled by sulfide tetrazines as a single end-group moiety

Part of 2025 ACS Rising Stars in Polymers

(28) M. Kong, T. J. H. P. van den Braak, K. Neumann* ChemBioChem 2025, e202500490.

Aspartimide Formation and Its Prevention In Fmoc Chemistry Solid Phase Peptide Synthesis

(27) T. van den Elsen, K. Neumann*, Journal of Materials Chemistry B, 2025, 13, 8953-8974.

From Simple Delivery to Multimodal Systems: The Critical Role of Macromolecular Platforms in Bioorthogonal Drug Synthesis

(26) K. Neumann*, D. M. Sánchez-Cerrillo, D. Galimberti, Chemical Communications, 2025, 61, 8903-8906.

Poly(N-Acyliminophosphoranes): Main Chain Functionalized Poly(ylides) with pH-Dependent Degradation

Part of the themed collection: 2025 RSC Chemical Communications Emerging Investigators

(25) B. Berking, D. Karagrigoriou, D. Galimberti*, B. H. E. Zhang, D. Wilson*, K. Neumann*, ACS Langmuir, 2025, 41, 13, 8627–8636.

Water-Soluble Sulfur-Ylide-Functionalized Polyacrylamides for Antibacterial Surface Applications

(24) K. Neumann*, RSC Biomaterials Science, 2024, 12, 5481.

The case for poly(ylides) as a class of charge-neutral, hydrophilic polymers with applications in biomaterials science

(23) F. P. J. T. Rutjes, K. M. Bonger, K. Neumann*, synlett, 2024, 35, 1230-1238.

Bioorthogonal Chemistry at Radboud University: Past, Present and Future – Invited Article as part of the 7th Graham Workshop in Nagasaki, Japan

(22) L. M. Bickem, K. Gavriel, K. Neumann*, European Journal of Organic Chemistry, 2024, 27, 3, e202301117.

Accessing Functionalized Tetrazines as Click Chemistry Tools: A Synthesis Guide for Chemists and Chemical Biologists – Editors Choice

(21) D. Karagrigoriou, B. B. Berking, Q. Wang, D. M. Sánchez-Cerrillo, D. R. Galimberti, D. A. Wilson, K. Neumann*, ACS Macro Letter, 2023, 12, 12, 1608.

Unveiling the Antifouling Potential of Stabilized Poly(phosphorus ylides)

(20) D. Kumar, P. F. Kuijken, T. van de Poel, K. Neumann*, D. Galimberti*, Chemistry – A European Journal, 2024 30, 7, e202302596.

Revealing the unique role of water in the formation of benzothiazoles: an experimental and computational study – HOT article

(19) D. W. T.Geers, K. Gavriel, K. Neumann*, Journal of Peptide Science, 2024, 30, 3, e3548.

Rapid, traceless and facile peptide cyclization enabled by tetrazine-thiol exchange

Part of the themed collection: Peptide Talents

(18) B. B. Berking, D. Karagrigoriou, G. Poulladofonou, D. A. Wilson, K. Neumann*, Angewandte Chemie, 2023, accepted, e202308971.

Zwitterionic Polymeric Sulfur Ylides with Minimal Charge Separation Open a New Generation of Antifouling and Bactericidal Materials

Press Release by Angewandte Chemie: Repellant and Hostile to Bacteria
Highlighted in ChemistryViews

(17) K. Gavriel, D. van Doeselaar, D. W. T. Geers, K. Neumann*, RSC Chemical Biology, 2023, 4, 685-691.

Click’n lock: Rapid exchange between unsymmetric tetrazines and thiols for reversible, chemoselective functionalisation of biomolecules with on-demand bioorthogonal locking

Part of the themed collection: 2023 RSC Chemical Biology Emerging Investigators

(16) R. Remmers, K. Neumann*, Biomater. Sci., 2023, 11, 1607.

Reaching new lights: A review on photo-controlled nanomedicines and their in vivo evaluation

(15) G. Poulladofonou, K. Neumann*, Polymer Chemistry, 2022, 13, 4416.

Poly(sulfur ylides): A new class of zwitterionic polymers with distinct thermal and solution behaviour

Publications at ETH Zurich and Edinburgh University

(14) K. Neumann, A. Vujinovic, S. Kamara, Andre Zwicky, S. Baldauf, J. Bode, RSC Chemical Biology, 2023, accepted article.

Synthesis of Multi-Module Low Density Lipoprotein Receptor Class A Domains with Acid Labile Cyanopyridiniumylides (CyPY) as Aspartic Acid Masking Groups

(13) J. Geng, Y. Zhang, Q. Gao, K. Neumann, H. Dong, H. Porter, M. Potter, H. Ren, D. Argyle and M. Bradley, Nature Chemistry, 2021, 13, 805.

Switching on prodrugs using radiotherapy

highlighted in synform: 2022/01, A14–A18.

(12) G. Wang, L. Qiu, X. Li, Y. Pan, Y. Sheng, K. Neumann, Y. Sun, Y. Wang, L. Liu, L. Deng, M. Bradley, R. Zhang, Biomed Phys Eng Express, 2020, 6, 2, 025005.

Novel copolymers drive differentiation of human adipose derived stem cells towards chondrocytes and osteoblasts identified by high-throughput approach

(11) D. Schauenburg, M. Divandari, K. Neumann, C. A. Spiegel, T. Hackett, Y. Dzeng, N. D. Spencer and J. W. Bode, Angewandte Chemie, 2020, 59, 14656.

Synthesis of polymers containing potassium acyltrifluoroborates (KATs) and post-polymerization ligation and conjugation

(10) K. Neumann, J. Farnung, S. Baldauf and J. W. Bode, Nature Communication, 2020, 11, 982.

Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

(9) K. Neumann*, A. Gambardella and M. Bradley*, ChemBioChem, 2019, 7, 872.

The Emerging Role of Tetrazines in Drug-Activation Chemistries

(8) K. Neumann^†*, A. Gambardella^†, A. Lilienkampf and M. Bradley*, Chem. Sci. 2018, 9, 7198.

Tetrazine-mediated bioorthogonal prodrug–prodrug activation

(7) K. Neumann*, A. Lilienkampf and M. Bradley*, Polym Int, 2017, 66, 1756.

Responsive polymeric nanoparticles for controlled drug delivery

(6) K. Neumann^†, A. C. Gonzalez^†, M. Owens, A. Venturato, Y. Zhang, J. Geng and M. Bradley, Macromolecules, 2017, 50, 6026.

An Approach to the High-Throughput Fabrication of Glycopolymer Microarrays through Thiol–Ene Chemistry

(5) X. Feng, G. Wang, K. Neumann, W. Yao, L. Ding, S. Li, Y. Sheng, Y. Jiang, M. Bradley and R. Zhang, Materials Science and Engineering: C, 2017, 74, 270.

Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

(4) K. Neumann, S. Jain, A. Gambardella, E. Valero, S. E. Walker, A. Lilienkampf and M. Bradley, ChemBioChem, 2017, 18, 91.

Tetrazine‐Responsive Self‐immolative Linkers

ChemBioChem Readers’ Choice – Most Read Articles in 2018 and 2019.

(3) G. Wang, Z. Duan, Y. Sheng, K. Neumann, L. Deng, J. Li, M. Bradley and R. Zhang, Chem. Commun. 2016, 52, 10521.

Tuning the emission properties of a fluorescent polymer using a polymer microarray approach – identification of an optothermo responsive polymer

(2) S. Jain^†, K. Neumann^†, Y. Zhang, E. Valero, J. Geng and M. Bradley, Macromolecules, 2016, 49, 5438.

Tetrazine-Mediated Postpolymerization Modification

(1) K. Neumann^†, S. Jain^†, J. Geng and M. Bradley, Chem. Commun., 2016, 52, 11223.

Nanoparticle “switch-on” by tetrazine triggering